Interstate 10 in New Mexico follows the former path of U.S. Route 80 across the state. Only three cities of significant size are located on the interstate: Lordsburg, Deming, and Las Cruces.
At Lordsburg is the western junction of U.S. Route 70 and a concurrency and the two highways are joined all the way to Las Cruces. Several exits between Lordsburg and Deming are either for former towns (including Separ, Quincy, and Gage) or lack any town at all.
At Deming is the western junction of U.S. Route 180, which also forms a concurrency with I-10 all the way to El Paso. One mile north of Deming on US 180 is New Mexico Route 26 which serves as a short cut to north I-25 and Albuquerque.
I-10/US 70/US 180 continue east to Las Cruces which is the southern end of Interstate 25. Also, US 70 leaves Interstate 10, heading northeast to Alamogordo. Interstate 10 then turns south to the Texas state line.